Factor XII (Hageman or Contact Factor) (Last Updated - 3/1/2005)
-involved in the initial step of the intrinsic pathway
-gets activated to form Factor XIIa (this process also creates kallikrein) via catalysis by:
1) Prekallikrein
2) High Molecular Weight Kininogen (HMWK)
3) & Kaolin
-click here to view an image of the clotting cascade
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.